Effects of Bifidobacterium Triplex on metabolic parameters and intestinal flora in patients with Parkinson's disease
Objective To observe the efficacy of Bifidobacterium Triplex in the treatment of Parkinson's disease(PD),providing a reference for the treatment.Methods A total of 82 patients with PD treated in our hospital from January 2023 to October 2023 were retrospectively selected and divided into groups according to different treatment methods.The con-trol group(40 cases)was given Levodopa and Benserazide Hydrochloride Tablets,the observation group(42 cases)was given Bifidobacterium Triplex on the basis of the treatment for control group.The total efficiency rates in the two groups were calculated.Athletic ability[unified PD rating scale Ⅱ(UPDRSⅡ)],activity of daily living[unified PD rating scale Ⅲ(UPDRS Ⅲ)],gut flora count,and metabolic parameters[total cholesterol(TC),triglyceride(TG),homeo-stasis model assessment isletβ-cell function index(HOMA-β)and homeostasis model assessment insulin resistance index(HOMA-IR)]were compared between groups before and after treatment.Results The total efficiency rate in obsevation group(76.19％)was higher than that in control group(55.00％)(P＜0.05).In terms of UPDRS Ⅱ and UPDRS Ⅲ scores,there were significant differences in the post-treatment comparison between groups(all P＜0.05).After 12 weeks of treatment,the counts of Bifidobacterium and Lactobacillus in observation group were higher,while those of yeast and Enterococcus were lower than those in control group,respectively(all P＜0.05).After 12 weeks of treatment,there were no significant differences in TC and TG levels between the two groups(P＞0.05),and the HOMA-β and HOMA-IR levels in the observa-tion group were lower than those in the control group(all P＜0.05).Conclusion Bifidobacterium Triplex has significant effect in the treatment of PD,which can regulate intestinal flora,improve metabolic parameters,and enhance athletic abil-ity and activity of daily living.
Bifidobacterium TriplexParkinson's diseaseMetabolic parametersGut microbesAthletic abilityActivity of daily living
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