首页|肠菌移植制备和质控实验室标准化技术规范中国专家共识(2023版)

肠菌移植制备和质控实验室标准化技术规范中国专家共识(2023版)

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肠菌移植也称粪菌移植(fecal microbiota transplantation,FMT),作为一种新兴的治疗手段已被尝试应用于多种疾病,FMT是重建肠道微生态的有效方法,是指将健康人粪便中的功能菌群处理以后移植到患者肠道内,重建新的肠道菌群,恢复肠道菌群的多样性和生物学功能,实现肠道内外疾病的治疗,达到治病的目的。在针对FMT的基础与临床研究领域,需要认识与了解FMT制备和质控的实验室检测方法。由于FMT技术的实验流程、质量管理等方面没有形成统一标准,为了明确FMT制备和质控实验室标准化技术规范,中国抗癌协会肿瘤与微生态专业委员会和中国感染免疫与微生态研究转化协作组组织有关专家共同讨论,提出《肠菌移植制备和质控实验室标准化技术规范中国专家共识(2023版)》,为FMT基础与临床领域进一步应用深入研究提供依据。
Chinese expert consensus on standardized technical specifications for laboratory preparation and quality control of fecal microbiota transplantation(2023 edition)
Fecal microbiota transplantation(FMT)has been attempted as an emerging therapeutic tool for a variety of dis-eases.FMT is an effective method to rebuild intestinal microecology,which refers to transplanting functional flora from healthy human feces into the patient's intestine after treatment to rebuild new intestinal flora and restore the diversity and biological of intestinal flora,so as to realize the treatment of diseases inside and outside the intestinal tract and achieve the purpose of curing diseases.In the field of basic and clinical research targeting FMT,there is a need to recognize and under-stand the laboratory assays for FMT preparation and quality control.Since there is no unified standard for the experimental procedure and quality management of FMT technology,in order to clarify the standardized laboratory technical specifica-tions for FMT preparation and quality control,the Tumor and Microecology Professional Committee of the Chinese Anti-Cancer Association and the Chinese Infection Immunology and Microecology Research Translation Collaborative Group organized relevant experts to discuss and propose the"Chinese Expert Consensus on Standardized Technical Specifica-tions for Laboratory Preparation and Quality Control of Fecal Microbiota Transplantation(2023 Edition)",which provides a basis for further application and in-depth research in the basic and clinical fields of FMT.

Fecal microbiota transplantationGut microecologyExperimental proceduresQuality controlTechnical spe-cificationsExpert consensus

中国抗癌协会肿瘤与微生态专业委员会、中国感染免疫与微生态研究转化协作组、郭智、王强

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华中科技大学协和深圳医院血液内科

中国抗癌协会肿瘤与微生态专业委员会

武汉科技大学医学部

肠菌移植 肠道微生态 实验流程 质量控制 技术规范 专家共识

2024

中国微生态学杂志
中华预防医学会 大连医科大学

中国微生态学杂志

CSTPCD北大核心
影响因子:1.115
ISSN:1005-376X
年,卷(期):2024.36(6)