Influences of serum amino acid levels and intestinal flora changes on pregnancy outcome in patients with gestational diabetes mellitus
Objective To observe the effects of serum amino acid levels and intestinal flora changes on pregnancy out-comes in patients with gestational diabetes mellitus(GDM).Methods A total of 256 GDM patients who received prenat-al examination and delivered in our hospital from January 2015 to December 2022 were selected as the GDM group,and 253 healthy pregnant women in the same period were selected as the control group.Serum amino acid levels and intestinal flora were detected in the two groups.The adverse pregnancy outcomes in the two groups were statistically analyzed.The GDM patients were classified into the normal pregnancy outcome group and the adverse pregnancy outcome group.The serum amino acid levels and intestinal floral distributions in the two groups were analyzed,and the influences of serum amino acid level and intestinal flora on pregnancy outcome were analyzed.Results The differences in levels of serum alanine,glycine,methionine and arginine and in the distribution of Bacteroides,Bifidobacterium,Enterococcus,Lactoba-cillus and Enterobacteriaceae between GDM group and control group were statistically significant(t=7.090,7.789,20.762,10.124,17.995,21.134,14.989,18.189,4.428;all P＜0.05).Compared with the control group,the total incidence of ad-verse pregnancy outcomes in the GDM group was significantly higher(x2=14.047,P＜0.05).The levels of alanine and me-thionine in the adverse pregnancy outcome group were significantly higher,and those of glycine and arginine were signific-antly lower;the counts of intestinal Lactobacillus and Bifidobacterium.were significantly lower,and those of Bacteroides,Enterococcus and Enterobacteriaceae were significantly higher than those in the normal pregnancy outcome group,re-spectively(t=3.541,3.790,2.596,4.605,3.434,14.049,7.165,3.839,4.612;all P＜0.05).Logistic multifactorial regres-sion analysis showed that alanine and methionine were independent risk factors for adverse pregnancy outcomes,and gly-cine,arginine,Lactobacillus and Bifidobacterium were independent protective factors for adverse pregnancy outcomes(all P＜0.05).Conclusion In GDM patients,serum amino acid levels increased,intestinal pathogenic bacteria increased and probiotics decrease.Changes in serum amino acid levels and intestinal flora can greatly affect the outcome of pregnancy,so clinical attention should be paid to this issue,and relevant intervention measures should be taken.
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