Application of fecal microbiota transplantation in treatment of neuropsychiatric disorders
Recently,more and more studies have shown that the gut microbiota can participate in the bidirectional regula-tion of the gut and central nervous system through neurotransmitter,endocrine,immune and metabolic pathways.The brain can also regulate the structural composition of the gut microbiota,adapt to environmental changes and maintain intestinal microecological balance.These findings have gradually formed a new medical research hotspot,the"Microbiota-Gut-Brain Axis"(MGB),which is closely related to a series of neuropsychiatric diseases such as autism,Parkinson's disease,Alzheimer's disease,affective disorders,anxiety and Schizophrenia.The reconstruction of healthy intestinal flora is a new strategy for the treatment of brain diseases,and intestinal microbiota transplantation(FMT)is considered an effective means of rebuilding the intestinal microbiota.With the deepening of FMT research,some important research progress has been made in the treatment of neuropsychiatric diseases with FMT.This article mainly reviews the application,safety and limitations of FMT in the treatment of neuropsychiatric diseases.
Gut microbiotaFecal microbiota transplantationNeuropsychiatric affectionsSaftyLimitation
NETL
NSTL
万方数据
