首页|具有新一代益生菌潜能的罗氏菌在各类疾病中调节作用的研究进展

具有新一代益生菌潜能的罗氏菌在各类疾病中调节作用的研究进展

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肠道菌群与宿主之间存在着密不可分的互惠共生关系,菌群异常与疾病的发生发展密切相关。国内外研究发现了一种革兰阳性厌氧菌——罗氏菌(Roseburia),它能产生对人体有益的短链脂肪酸(尤其是丁酸)。罗氏菌可调节宿主代谢、肠道屏障和肠道菌群组成,对机体有益,显示出良好的开发和应用前景,有望成为新一代的益生菌。然而,目前对罗氏菌的研究仍局限于其丰度和短链脂肪酸的产量上,并没有关注罗氏菌本身对人体健康的调节作用。本文就罗氏菌在人体各种疾病中的改善作用作一概述,以期为进一步研究和开发罗氏菌提供参考。
Regulatory effects of Roseburia with potential of new generation of probiotics in various diseases:advances in research
There is an inseparable mutualistic relationship between intestinal microbiota and host,and abnormal microbi-ota is closely related to the occurrence and development of diseases.Recently,researches at home and abroad found a Gram-positive anaerobe bacteria,Roseburia,the bacterium produces short chain fatty acids(especially butyrate)which are beneficial to human body.Roseburia can affect the metabolisms of the host,promote intestinal barrier and regulate the composition of intestinal microbiota,therefore possess a good prospect for development and application,and is expected to become a next generation of probiotics.However,the perspective of the research on Roseburia is still limited to the abund-ance of the Roseburia and its output of short-chain fatty acids,and the effect of Roseburia itself on human body health has not been paid attention to.This paper summarizes the role of Roseburia in various diseases of human body,and provides reference for further systematic research and development of Roseburia.

RoseburiaProbioticsShort chain fatty acidsDiseases

艾方彬、岳备、高瑞阳、王子怡、窦薇

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上海中医药大学中药研究所暨上海市复方中药重点实验室,上海 201203

罗氏菌 益生菌 短链脂肪酸 疾病

国家自然科学基金上海市自然科学基金

8227432920ZR1458000

2024

中国微生态学杂志
中华预防医学会 大连医科大学

中国微生态学杂志

CSTPCD北大核心
影响因子:1.115
ISSN:1005-376X
年,卷(期):2024.36(6)