Microbial diversity in different parts of the digestive tract in celiac disease
Celiac disease(CD)is an autoimmune disease of the small intestine caused by the ingestion of gluten protein in genetically susceptible individuals.Microecological imbalance may lead to the infection by pathogenic microorganisms in the digestive tract,which cause persistent intestinal inflammation,disrupting intestinal immune homeostasis and participat-ing in the pathophysiological process of CD.The functional heterogeneity of different parts of the digestive tract can lead to regional differences in intestinal microbes.Since the composition of intestinal microorganisms depends largely on the sampling site,this article will review the relationship between the microecological imbalance in different parts of the di-gestive tract and CD from three aspects:the microbiota in different parts of the digestive tract,the changes of microbiota in different parts of the digestive tract after gluten-free diet treatment,and the relationship between CD and fungal microbiota,in order to help promoting the development of microorganism-targeting strategies for CD prevention and treatment.
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