Characterization of gut microbiota in patients with type 2 diabetes mellitus
Objective Based on data from type 2 diabetes mellitus(T2DM)patients in different geographical regions,the characteristics of disease-specific gut microbiota were analysed to provide a referable means for clinical diagnosis of T2DM,as well as data to support targeted probiotic interventions for T2DM patients.Methods By downloading faecal macrogenomic data from public databases of 89 patients with T2DM(T2DM group)and 48 healthy individuals(HC group),the characteristics of the gut microbiota of T2DM patients were analysed.Results Patients with T2DM had a dis-turbed gut microbiota,characterised by increased microbial diversity;Dorea longicatena,Dorea formicigenerans and Cop-rococcus catus significantly increased,and significant changes in gut energy metabolism,carbohydrate metabolism,amino acid metabolism and secondary bile acid metabolites such as deoxycholic acid and lithocholic acid of decreased SCFAs-producing bacteria such as Phascolarctobacterium faecium were observed.In addition,there were significant differences in the disease-characterising microorganisms and their metabolic pathways in the patients from different geographical regions(46 patients from the North and 43 patients from the South),which might be related to factors such as place of residence,diet and lifestyle.Conclusion The results clarified the characteristic gut microbiota and metabolic pathways of T2DM pa-tients,and provided data for precise nutritional intervention for T2DM patients based on gut microbiota.
Type 2 diabetes mellitusGut microbiotaMetagenomicMetabolic pathway
NETL
NSTL
万方数据
