Causal relationship between intestinal flora and diabetic neuropathy:a two-sample Mendelian randomisation analysis
Objective To explore the correlation between gut microbiota and diabetic neuropathy using Mendelian ran-domisation.Methods Using the GWAS data of gut microbiota from the public database MiBioGen study and the GWAS data of diabetic neuropathy from the Finnish database,independent genetic loci significantly associated with the relative abundance of 211 species of gut microbiota were extracted according to preset thresholds as instrumental variables.The analyses were mainly performed using the inverse variance weighting method,and the results were assessed based on the effect indicator Odds ratio and 95％confidence interval.In addition,the stability and reliability of the results were verified using the leave-one-out method,heterogeneity test,and horizontal gene pleiotropy test.Results The results showed a causal relationship between intestinal flora and diabetic neuropathy,in which genera Eubacterium coprostanoligenes,Ac-tinobacteria,Bifidobacterium and Peptococcaceae might be protective factors against diabetic neuropathy,whereas Christensenellaceae R7 group,Eggerthella and Ruminococcaceae UCG-013 were potential risk factors for diabetic neuro-pathy.Conclusion Eubacterium coprostanoligenes,Actinobacteria,Bifidobacterium and Peptococcaceae reduced the risk of diabetic neuropathy,whereas the Christensenellaceae R7 group,Eggerthella and Ruminococcaceae UCG-013 were asso-ciated with an increased risk of diabetic neuropathy.Our study supports a potential causal relationship between several gut flora and diabetic neuropathy.Further studies are needed to investigate how gut flora affects the development of diabetic neuropathy.
NETL
NSTL
万方数据
