Effect of probiotics combined with compound Glycyrrhizin glycoside for hepatitis B cirrhosis and its influences on gut microbiota and serum inflammatory factors
Objective To observe the effect of probiotics combined with compound Glycyrrhizin glycoside(CGG)for hepatitis B cirrhosis,and its influences on gut microbiota and serum inflammatory factors,providing a reference for the treatment.Methods A total of 108 patients with hepatitis B(HB)cirrhosis admitted to our hospital from June 2020 to December 2022 were randomly grouped into a control group(54 cases)and an experimental group(54 cases).All the pa-tients were treated with entecavir;on this basis,the control group was given CGG,while the observation group was treated with CGG and Bifidobacterium Tetragenous Viable Bacteria(BTVT).The efficacies in the two groups were determined,and the gut microbiota,serum inflammatory factor[interleukin(IL)-6,tumor necrosis factor-α(TNF-α)]levels and liver function indicators[alanine transaminase(ALT),aspartate transaminase(AST),total bilirubin(TBIL)]were compared between groups before treatment and after 6 months of treatment.Results The total efficiency rate in the experimental group was higher than in the control group(94.44％vs 79.63％,P＜0.05).After 6 months of treatment,the counts of Bi-fidobacterium and Lactobacillus in the experimental group were higher than before treatment and the control group at same time(all P＜0.05),while that of Escherichia coli was lower than those before treatment respectively and those in the con-trol group at same time(all P＜0.05),respectively.After 6 months of treatment,the serum levels of IL-6,TNF-α,ALT,AST and TBIL in the experimental group were lower than those before treatment and those in the control group at same time,respectively(all P＜0.05).Conclusion The effect of BTVB combined with CGG for patients with HB cirrhosis is better,which can effectively regulate gut microbiota,reduce inflammatory reactions,and obviously improve liver function.
Bifidobacterium tetragenous viable bacteriaCompound glycyrrhizin glycosideHepatitis BLiver cirrhosisGut microbiota
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