Effects of probiotics combined with Ulinastatin on intestinal flora,gastrointestinal function and immune function in patients with septic shock
Objective To observe the effect of probiotics combined with Ulinastatin on septic shock patients,providing a reference for the treatment.Methods A total of 80 patients with septic shock diagnosed and treated in our hospital from July 2021 to July 2023 were retrospectively enrolled and divided into different groups according to the treatment plans.All of the patients were given conventional treatment;38 cases in the single drug group were given Ulinastatin and 42 cases in the combination group were given probiotics combined with Ulinastatin.The clinical efficacy and indicator levels were compared between the two groups.Results The SOFA and APACHE Ⅱ scores[(5.08±1.07)score and(12.75±2.48)score]in combination group were lower than those in single drug group[(7.16±1.54)score and(15.66±3.23)score]after treatment(t=7.707,4.544;all P＜0.05).After treatment,the counts of intestinal Lactobacillus and Bifidobacterium in com-bination group[(5.91±1.02)lg CFU/g,(6.72±1.23)lg CFU/g]were higher than those in single drug group[(5.24±0.85)lg CFU/g,(5.82±1.06)lg CFU/g],while that of Staphylococcus[(3.77±0.32)lg CFU/g]was lower than that in single drug group[(4.28±0.43)lg CFU/g](t=3.173,6.055,3.488;all P＜0.05).The levels of GAS,MOT,IgA,IgG and IgM after treatment in combination group[(67.56±24.82)pg/mL,(408.52±118.47)pg/mL,(2.61±0.43)g/L,(12.24±1.36)g/L,(1.52±0.25)g/L]were better than those in single drug group[(94.30±30.88)pg/mL,(326.39±107.76)pg/mL,(2.18±0.37)g/L,(10.45±1.13)g/L,(1.14±0.22)g/L](t=4.287,3.232,4.770,6.365,7.184;all P＜0.05).Conclusion Probiotics com-bined with ulinastatin have excellent effects in the treatment of septic shock,which can adjust the imbalance of intestinal flora,enhance gastrointestinal function and immune function,and improve the prognosis.
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