Correlation between serum inflammatory cytokines and gut microbiota in patients with endometriosis
Objective To explore the correlation between serum inflammatory cytokines and gut microbiota in patients with endometriosis(EMS),providing a reference for the treatment.Methods A total of 400 patients with EMS and 100 healthy controls in the hospital between April 2020 and April 2023 were enrolled as EMS group and control group,respect-ively.The levels of serum inflammatory cytokines and gut microbiota were compared between the two groups.The rela-tionship between serum inflammatory cytokines and gut microbiota in EMS patients was analyzed using Pearson correla-tion analysis.Results The levels of serum IL-1β,IL-17,TGF-β1 and IL-22 in EMS group were(11.67±1.24)ng/L,(78.16±7.13)ng/L,(1.93±0.42)μg/L and(359.48±56.39)ng/L,higher than(4.05±0.98)ng/L,(52.02±6.58)ng/L,(1.51±0.34)μg/L and(203.54±57.11)ng/L in control group(t=57.137,34.933,9.267,24.671,all P＜0.05).The counts of Enterobacter and Clostridium perfringens in EMS group were(8.34±1.47)lg CFU/g and(8.69±1.32)lg CFU/g,higher than(5.36±1.18)lg CFU/g and(6.13±1.27)lg CFU/g in control group(t=1 8.809,17.476;all P＜0.05),while those of Lactoba-cillus and Bifidobacteria were(4.12±0.86)lg CFU/g and(7.11±1.32)lg CFU/g,lower than(7.41±1.05)lg CFU/g and(9.59±1.07)lg CFU/g in control group(t=32.661,17.408;all P＜0.05).The levels of serum IL-1β,IL-17,TGF-β1 and IL-22 were positively correlated with counts of Enterobacter and Clostridium perfringens(inflammatory factor-Enterobacter:r=0.621,0.675,0.589,0.637;inflammatory factor-Clostridium perfringens:r=0.543,0.612,0.572,0.511;all P＜0.05),while negatively correlated with counts of Lactobacillus and Bifidobacteria(inflammatory factor-Lactobacillus:r=-0.578,-0.509,-0.624,-0.582;serum inflammatory factor-Bifidobacteria:r=-0.529,-0.517,-0.538,-0.546;all P＜0.05).Conclusion The levels of serum IL-1β,IL-17,TGF-β1 and IL-22 are increased,and gut microbiota are disordered in EMS patients.There is certain relationship between serum inflammatory cytokines and gut microbiota.Clinically,treat-ment can be performed based on the improvement of inflammation level and gut microbiota.
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