Effects of antibiotics on gut microbiota and metabolism:research progress
The application of antibiotics is the pillar of the treatment of intestinal and systemic infectious diseases,and gut microbiota of human body is involved in the maintenance of various physiological functions.The use of antibiotics may change the composition of microorganisms and affect the metabolites of microbiota,such as short-chain fatty acids,lipo-polysaccharides,etc.,thus changing nerve conduction and liver physiological functions.The changes of gut microbiota un-der the action of antibiotics also play an important role in blood sugar,blood fat and immune function,and participate in the homeostasis of the body's internal environment.In the brain-gut axis system,changes in bacterial metabolites induced by antibiotic action affect the expression of these neurotransmitters and thus affect the neuropsychiatric state of the host.This paper reviews the changes in microbial composition and mechanism under the action of antibiotics,providing new ideas for the treatment of related diseases from the perspective of regulating gut microbiota.
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