Correlations of blood glucose and liver function indicators with gut microbiota diversity in patients with non-alcoholic liver disease
Objective To observe the characteristics of gut microbiota in patients with non-alcoholic liver disease(NALD)and analyze its correlations with blood glucose and liver metabolic indicators.Methods A total of 83 subjects were recruited from the outpatient department of our hospital from March 2023 to October 2023,including 33 patients with NALD(liver disease group)and 50 healthy individuals(control group).Fecal samples were collected;16S rRNA gene se-quencing and alpha diversity and beta diversity analyses were performed by using Illumina platform.Spearman rank correl-ation was used to analyze the relationship of blood glucose and liver function index levels with gut microbiota diversity.Results Compared with the control group,the alpha diversity of intestinal flora in liver disease group significantly de-creased(t=2.693,P=0.027);the Firmicutes with decreased abundance showed a significant negative correlation with HbA1c(r=-0.389,P=0.025),while the Bacteroidetes with increased abundance showed a significant positive correlation with HbA1c(r=0.389,P=0.025).In liver disease group,Faecalibacterium and Roseburia with decreased abundance were significantly negatively correlated with HbA1c(r=-0.494,-0.359;P=0.003,0.040),while Prevolla with decreased abund-ance was significantly positively correlated with HbA1c and ALT(r=0.448,P=0.009;r=0.410,P=0.018),and the Bac-teroides with increased abundance was significantly negatively correlated with HbA1c and ALT(r=-0.351,P=0.045;r=-0.393,P=0.024).Conclusion The structure of gut microbiota in patients with NALD has significantly changed,and changes in gut microbiota abundance are accompanied by varying degrees of changes in HbA1c and ALT indicators.These bacteria may contribute to the diagnosis,prevention,and treatment of NALD.
Non alcoholic liver diseaseGut microbiotaBlood sugarLiver function indicators
万方数据
维普
