Effects of traditional Chinese medicine atomization combined with acupuncture on inflammatory reaction and sputum flora in patients with phlegm-heat stagnation lung-type AECOPD
Objective To observe the effects and mechanisms of combined application of herbal nebulisation and acu-puncture therapy for improving the inflammatory state and structural changes of sputum flora in patients with acute exacer-bation of chronic obstructive pulmonary disease(AECOPD)with phlegm-heat stagnation lungs.Methods One hundred patients with AECOPD of phlegm-heat stagnation type admitted to our hospital between March 2022 and September 2023 were randomly divided into the observation group(50 cases,receiving treatment with conventional Western medicine,acu-puncture and traditional Chinese medicine atomization),and the control group(50 cases,receiving treatment with conven-tional Western medicine and acupuncture).Clinical efficacy,inflammatory response,lung function,relative abundance and diversity of sputum flora and incidence of adverse reactions were compared between the two groups.Results Compared to the control group,the overall efficiency rate in the observation group was higher(P＜0.05).The levels of serum C-react-ive protein(CRP)(t=19.926,P＜0.001)and interleukin-6(IL-6)(t=31.111,P＜0.001)in the observation group were lower than those in the control group after treatment(P＜0.05).The observation group exhibited higher values of forced expirat-ory volume(FEV1)(t=4.633,P＜0.001),forced vital capacity(FVC)(t=6.449,P＜0.001)(FEV1/FVC)(t=6.449,P＜0.001),and maximum ventilation volume per minute(MMV)(t=12.698,P＜0.001)in comparison to the control group(P＜0.05).At the phylum level,the relative abundance of Bacteroidetes in the observation group was higher than that in the control group after treatment.At the genus level,the relative abundances of Porphyromonas,Veillonella and Burkholderia in the observation group were lower,while those of Neisseria,Haemophilus,Alloprevotella,Prevotella-7 and Porphyromo-nas were lower than in the control group respectively after treatment.After treatment,the Chaol index,Ace index and Shannon index in the observation group were higher,while Simpson index was lower than those in the control group re-spectively(P＜0.05).The incidence of adverse events did not significantly vary between the two groups(P＞0.05).Conclusion Treatment with herbal nebulization combined with acupuncture significantly improves overall effectiveness in patients with phlegm-heat obstructive lung-type AECOPD.It effectively reduces inflammatory markers such as CRP and IL-6,and enhances lung function indicators including FEV1,FEV1/FVC and MMV.Additionally,the treatment improves sputum microbiota diversity by increasing beneficial microbes and reducing pathogens.There was no significant difference in adverse reactions between the two groups,indicating good safety of the treatment.
万方数据
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