Changes of oral microbiota and effect of compound Scutellaria baicalensis gargle in nasopharyngeal carcinoma patients undergoing radiotherapy
Objective To observe the changes in oral microbiota in patients with nasopharyngeal carcinoma(NPC)un-dergoing radiotherapy,and explore the effect of compound Scutellaria baicalensis gargle(SBG)on their oral microbiota and incidence of oral mucosal reactions.Methods The clinical data of 68 NPC patients treated in our hospital from June 2019 to June 2023 were retrospectively analyzed and recorded as the observation group.According to the gargles used dur-ing radiotherapy,they were further divided into two subgroups:group A(compound SBG,36 cases)and group B(saline gargle,32 cases).The physical examination data of 30 healthy volunteers in the same period were recorded as the health group.The oral flora composition in the observation group was compared with that in the health group before radiotherapy.The oral flora compositions of group A and group B were compared before and after radiotherapy.The oral mucosal reac-tions during radiotherapy were compared between group A and group B.Results The relative abundances of Bacteroid-etes,Proteobacteria,Actinbacteria,Spirochaetes,Streptococcus,Porphyromonas,Haemophilus and other genus were high-er than those of the healthy group(all P＜0.05),while the Firmicutes,Fusobacteria,Rothia,Rolstonia,Veronicus,Lactoba-cillus,Neisseria,Prevotclla were lower than those of the healthy group(all P＜0.05).After treatment,oral Bacteroidetes,Proteobacteria,Actinbacteria,Spirochaetes,Rolstonia,Veronicus,Porphyromonas,Neisseria and Prevotclla decreased in group A(all P＜0.05),and were lower than those in group B(all P＜0.05).The oral Firmicutes,Fusobacteria,Rothia,Streptococcus,Porphyromonas,Lactobacillus,Haemophilus increased in group A(all P＜0.05),and were higher than those in group B(all P＜0.05).The changes in oral flora of patients in group B were dominated by Porphyromonas and Veronicus after treatment,and the differences between the group A and group B before and after treatment were significant(all P＜0.05).Conclusion The relative abundance of Bacteroidetes,Proteobacteria,Actinbacteria,Spirochaetes,Strepto-coccus,Porphyromonas,Haemophilus and other genera in oral microbiota of NPC patients with radiotherapy increased,while those of Firmicutes,Fusobacteria,Rothia,Rolstonia,Veronicus,Lactobacillus,Neisseria decreased.Compound Scu-tellaria baicalensis gargle can improve the oral microbiota disorder in NPC radiotherapy patients,and effectively reduce the incidence of oral mucosal reactions.
万方数据
维普
