Role of probiotics in enhancing the efficacy and immune function of patients with chronic hepatitis B and cirrhosis based on real-world data
Objective To explore the effects of probiotics on the efficacy and immune function of patients with chronic hepatitis B(CHB)and cirrhosis based on real-world data.Methods The reports on 1,068 cases of CHB and cirrhosis from the third class general hospital information system(HIS)from May to December 2022 in Nantong city were investig-ated and analyzed,which were divided into Group A(n=796,probiotics used)and Group B(n=272,probiotics not used)based on whether probiotics were used.The Group A was further divided into groups A1,A2,A3 and A4 according to the category of microecological agents.The efficacy,liver function and cellular immune function before and after treatment and complications were compared among the groups.Results After 3 months and 6 months of treatment,the total effi-ciency rates in group A were higher than those in group B(84.93％vs 61.14％,92.63％vs 64.95％,all P＜0.05).After treatment,the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TB-IL)in group A were lower than before treatment and those in group B after treatment(all P＜0.05).The levels of CD4+cell,CD4+/CD8+and natural killer(NK)cell in group A were higher,while that of CD8+cell was lower than those before treatment and those in group B after treatment,respectively(all P＜0.05).The incidence of complications in group A was lower than that in group B(P＜0.05).After 3 months and 6 months of treatment,the total efficiency rates in the groups A1,A2 and A3 were higher than those in the group A4(86.89％,85.29％,89.23％vs 66.00％;95.53％,92.11％,97.22％vs 71.88％;all P＜0.05).After treatment,ALT,AST and TBIL in the groups A1,A2,A3 and A4 were lower than those be-fore treatment(all P＜0.05),and those in groups A1,A2 and A3 groups were lower than that in group A4(all P＜0.05).CD4+cell,CD4+/CD8+and NK cell in groups A1,A2,A3 and A4 after treatment were higher,while CD8+cell was lower than those before treatment,respectively(all P＜0.05).CD4+cell,CD4+/CD8+and NK cell in groups A1,A2 and A3 after treatment were higher,while CD8+cell was lower than those in group A4,respectively(all P＜0.05).The incidences of complications in the groups A1,A2 and A3 were lower than that in group A4(all P＜0.05).Conclusion Microecological preparations can enhance the therapeutic effect,liver function and cellular immune function of patients with CHB and cir-rhosis,and reduce complications.The effects of Bifidobacterium Triple Viable Bacteria,Bifidobacterium and Lactobacil-lus Triple Viable Bacteria,Bifidobacterium Tetravalent Viable Bacteria are better than other microecological agents.
万方数据
维普
