Effect of probiotics combined with conventional therapy on AIDS-related diarrhea and its influence on intestinal microecology
Objective To observe the effect of probiotics combined with conventional therapy on AIDS-related diarrhea,providing a reference for the treatment.Methods A total of 97 cases of AIDS-related diarrhea diagnosed and treated in our hospital from June 2020 to June 2023 were divided into conventional group(n=47)and experimental group(n=50)ac-cording to treatment methods.The former group received conventional therapy while the latter received probiotics com-bined with conventional therapy.The efficacy in the two groups was observed.Results After two weeks of treatment,the scores of Bristol fecal trait scale and Hart diarrhea scale in experimental group[(13.45±2.29)score,(8.26±1.68)score]were lower than those in conventional group[(18.16±3.65)score,(12.82±2.03)score](t27.662,12.082,all P＜0.05);the counts of Enterococcus and Enterobacter in experimental group[(5.03±0.84)lg CFU/g,(6.39±0.86)lg CFU/g]were lower than those in conventional group[(6.25±1.07)lg CFU/g,(7.25±1.02)lg CFU/g],while those of Lactobacillus and Bi-fidobacterium in experimental group[(8.20±1.48)lg CFU/g,(8.12±1.43)lg CFU/g]were higher than those in conventional group[(6.42±1.17)lg CFU/g,(6.69±1.22)lg CFU/g](t=6.266,4.499,6.544,5.282,all P＜0.05);the levels of MIP-2,IL-6,IL-10 and the counts of CD3+cell,CD4+cell and CD8+cell in experimental group[(70.59±4.24)pg/L,(9.69±1.30)μg/mL,(84.63±7.84)ng/L,(52.45±7.29)units/mm3,(33.59±7.04)units/mm3,(22.26±3.68)units/mm3]were superior to those in conventional group[(82.25±5.58)pg/L,(13.48±1.91)μg/mL,(73.52±6.56)ng/L,(47.16±6.65)units/mm3,(26.75±5.93)units/mm3,(27.82±4.03)units/mm3](t=11.631,11.485,7.544,3.726,5.159,7.102;all P＜0.05).Conclusion Probiot-ics combined with conventional therapy are effective in the treatment of AIDS-related diarrhea,which can regulate intestin-al microecology,reduce inflammation,improve immune function and promote the remission of clinical symptoms.
ProbioticsAIDSDiarrheaIntestinal floraImmune function
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