Effects of Lacticaseibacillus rhamnosus HN001 and Enterococcus DM891129 on blood lipid levels in hyperlipidemia mice during pregnancy
Objective To observe the effects of probiotics on the lipid metabolism of hyperlipidemia mice during preg-nancy,and provide evidence for the development of probiotics that can be used during pregnancy.Methods A total of 24 female 8 week old SPF Balb/c mice,averege weight of which was 18 gram,were randomly divided into control group,model group,Lacticaseibacillus rhamnosus HN001 group and Enterococcus DM891129 group,6 mice in each group.Ex-cept the normal diet in the control group,the other groups were fed high-fat diet.Four weeks later,the female mice were caged with 12 8 week old SPF male mice together,and the female mice were considered to be pregnant when vaginal em-bolus appeared.After successful conception,the Lacticaseibacillus rhamnosus HN001 group and Enterococcus DM891129 group were given gastric administration of the corresponding probiotics until Day 15 of pregnancy.The blood and liver of female mice were collected to detect lipid levels,inflammatory factors and oxidative stress levels in the liver,and the body length and weight of the offsprings were evaluated.Results The weights of pregnant mice with hyperlipidemia were de-creased by the intervention of both Lacticaseibacillus rhamnosus HN001 and Enterococcus DM891129.Enterococcus DM891129 intervention increased the weights of offsprings,but had little effect on the number of offspring.Enterococcus DM891129 effectively reduced the levels of blood lipids and inflammatory factors,and relieved that of oxidative stress in liver tissue of pregnant mice with hyperlipidemia.Conclusion Enterococcus DM891129 can regulate the level of blood lipid in pregnant mice with hyperlipidemia.
ProbioticsHyperlipidemia during pregnancyMiceLipid level
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