Network pharmacological analysis of modified Simiao Yong'an Decoction in regulating gut microbiota for the treatment of hyperuricemia
Objective To explore the molecular mechanism of modified Simiao Yong'an Decoction(MSYD)in treating hyperuricemia(HUA)by regulating the gut microbiota through network pharmacology analysis.Methods The active in-gredients of MSYD were searched and filtered from the TCMSP database,and gut microbial metabolites were retrieved from the gutMGene database,along with the collection of related targets.Targets related to HUA were searched in the GeneCards,OMIM,and DisGeNet databases.Common targets were obtained by taking the intersection of the active in-gredients targets and HUA targets,and then the intersection of the common targets and the intestinal microbiota targets was taken as the hub targets.A protein-protein interaction network of hub targets was constructed,and GO and KEGG enrich-ment analyses were performed.The main ingredients closely related to HUA and gut microbiota metabolites were screened,and molecular docking validation was conducted using AutoDock software.Results The key active ingredients of MSYD that improved HUA included quercetin,kaempferol and β-sitosterol,etc.Gut microbial metabolites such as succinate and butyrate were closely related to HUA,and MSYD might affect these metabolites by regulating the gut microbiota.Conclusion MSYD can intervene and treat HUA by regulating the gut microbiota through multiple components,targets and pathways.
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