Effects of Qinghua Yiwei Decoction combined with Qijiao moxibustion on Helicobacter pylori eradication rate and Musashi-1 mRNA expression in chronic atrophic gastritis with spleen deficiency Qi stagnation and blood stasis syndrome
Objective To observe the effects of Qinghua Yiwei Decoction combined with Qijiao moxibustion on Helico-bacter pylori(H.pylori)eradication rate and Musashi-1 mRNA expression in patients with chronic atrophic gastritis(CAG)of spleen deficiency Qi stagnation and blood stasis,providing a reference for the treatment.Methods A total of 200 pa-tients with CAG treated in our hospital from January 2022 to October 2023 were enrolled and randomly divided into 4 groups(n=50),receiving standard H.pylori quadruple therapy;additionally,based on this,the observation group 1 re-ceived Qinghua Yiwei Decoction,observation group 2 received Qijiao moxibustion,and observation group 3 received Qinghua Yiwei Decoction combined with Qijiao moxibustion.The clinical efficacy,inflammation level,Musashi-1 mRNA expression level,H.pylori eradication rate and quality of life were compared among the 4 groups.Results After treat-ment,the total efficiency rate in the observation group 3(92.00％)was the highest.In the 4 groups,the levels of interleukin-6(IL-6)and tumor necrosis factor α(TNF-α)decreased,and serum gastrin-17(G17)level increased.The levels of IL-6 and TNF-α in observation group 3 were lower,while G17 level was higher than in the control group,observation group 1 and observation group 2,respectively(all P＜0.05).After treatment,Musashi-1 mRNA expression level decreased in all groups,while that in the observation group 3 was lower than in the control group,observation group 1 and observation group 2,respectively(F=4.551,P＜0.05).H.pylori eradication rate in observation group 3(92.00％)was higher than in control group(74.00％),observation group 1(76.00％),and observation group 2(78.00％)resepctively(x2=4.204,P＜0.05).After treatment,the quality of life in the four groups was improved,and that in the observation group 3 was high-er than in the control group,observation group 1 and observation group 2,respectively(all P＜0.05).Conclusion Qinghua Yiwei Decoction combined with Qijiao moxibustion can inhibit the expression of Musashi-1 mRNA in chronic atrophic gastritis patients with spleen deficiency Qi stagnation and blood stasis syndrome,improve the eradication rate of H.pylori and quality of life,and reduce the inflammatory response,with significant effect.
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