The characteristics of intestinal microbiota in patients with esophageal squamous cell carcinoma
Objective To analyze the intestinal microbiota of patients with esophageal squamous cell carcinoma(EC)and healthy controls by using 16S rRNA gene sequencing technology,providing a reference for the treatment.Methods Fresh fecal specimens were obtained from 42 patients with EC,as well as 33 gender-and age-matched healthy controls,from Ju-ly 2023 to December 2023.The intestinal microbiota analysis was performed using 16S rRNA gene sequencing techno-logy.Results The results revealed significantly higher abundance of Proteobacteria and Actinobacteriota in EC group compared to NC control group.At the genus level,there was a significant increase in the abundances of Bifidobacterium,Escherichia-Shigella,Enterococcus,Blautia,Klebsiella,Collinsella and Bifidobacterium among patients with EC,while those of Bacteroides,Haemophilus,Dialister,Veillonella,Prevotella,Megamonas and Faecalibacterium were decreased.Conclusion 16S rRNA gene sequencing technology is expected to identify potential early warning factors related to the occurrence and progression of esophageal squamous cell carcinoma by monitoring changes within intestinal microbiota.
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