The effects of Shenling Baizhu Powder on clinical efficacy and intestinal flora in hyperlipidemia patients with spleen deficiency and dampness syndrome
Objective To observe the clinical effects of Shenling Baizhu Powder on hyperlipidemia patients with spleen deficiency and dampness syndrome,and explore the correlation between its mechanism of action and intestinal flora.Methods Sixty patients with hyperlipidemia due to spleen deficiency and dampness in our hospital were enrolled and randomly divided into the experimental group(n=30)and control group(n=30).Both groups were treated with Atorvastat-in,while the experimental group was treated with Shenling Baizhu Powder additionally,for 4 weeks.Blood tests and stool tests were used to observe the changes of blood lipid indexes,TCM syndrome scores and intestinal flora before and after intervention.Results After treatment,the serum levels of TC,TG and LDL-C significantly decreased in both groups of patients,while that of HDL-C significantly increased.The effect in the experimental group was better than in the control group.The TCM syndrome scores in both groups were lower after treatment,and that in the experimental group was lower than in the control group.The total efficiency rate in observation group was 93.33％,higher than the 73.33％in the control group.Alpha and beta diversity analysis revealed that the species richness of gut microbiota decreased in patients with hy-perlipidemia,spleen deficiency and dampness deficiency syndrome.After treatment,the experimental group showed a greater increase in species richness and diversity of gut microbiota compared to the control group(all P＜0.05).In terms of intestinal flora structure,there were significant differences between the two groups before and after treatment.After treat-ment,the abundances of Firmicutes and Actinobacteria significantly decreased,while those of Proteobacteria and Verruco-mycota significantly increased in the experimental group;at the genus level,the abundances of Escherichia-Shigella,Kleb-siella,Enterococcus and Akkermansia significantly increased.Biomarker analysis revealed that the sqrtIVt values of Cit-robacter,Enterobacterium,Morganella and Proteobacterium in the experimental group were higher than those in the other groups after treatment,which could be used as potential indicator species for this group.Conclusion Shenling Baizhu Powder can effectively improve the blood lipid indexes and TCM syndromes of hyperlipidemia in spleen deficiency and dampness syndrome,and its mechanism is related to the regulation of intestinal flora.
Shenling Baizhu PowderIntestinal floraSyndrome of spleen deficiency and dampnessHyperlipidemiaClin-ical efficacy
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