The correlation of group B Streptococcus infection with vaginal infection and pregnancy outcome in pregnant women with full-term premature rupture of membranes
Objective To explore the correlation of group B Streptococcus(GBS)infection with vaginal infection and pregnancy outcome in women with full-term premature rupture of membranes(FPROM),providing a reference for the treatment.Methods A total of 128 patients with FPROM admitted to our hospital from March 2020 to January 2023 were enrolled.Among them,22 patients with FPROM combined with GBS infection were included as the observation group,and 106 patients with FPROM without GBS infection were included as the control group.The correlation of vaginal infec-tion with vaginal fluid IL-6 and the adverse pregnancy outcomes were analyzed.Results The vaginal fluid IL-6 level in observation group was higher than in the control group(t=5.228,P＜0.001).The positive rates of trichomonas vaginitis and bacterial vaginosis in observation group were 13.64％(3/22)and 18.18％(4/22)respectively,obviously higher than in the control group[0.94％(1/106),3.77％(4/106)]respectively(x2=5.956,4.230;all P＜0.05).There was no obvious differ-ence in the positive rate of vulvovaginal candidiasis between the two groups(P＞0.05).The incidences of adverse preg-nancy outcomes such as neonatal pneumonia,fetal distress,neonatal asphyxia and preterm birth in observation group were higher than those in control group(x2=15.618,P＜0.001).The incidence rates of neonatal pneumonia,neonatal asphyxia and fetal distress in GBS and IL-6 positive parturients were higher than in GBS and IL-6 negative parturients(x2=12.079,17.336,11.058;all P＜0.05).Conclusion Premature rupture of membranes combined with GBS infection can increase the risk of vaginal infection and IL-6 level,and IL-6 is expected to become an important clinical indicator for predicting ad-verse pregnancy outcomes.
Premature rupture of membranesGroup B Streptococcus infectionVaginitisInterleukin-6
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