Impacts of Helicobacter pylori infection on glycolipid metabolism,coagulation function and pregnancy outcomes in patients with gestational diabetes mellitus
Objective To observe the impacts of Helicobacter pylori(H.pylori)infection on glycolipid metabolism,co-agulation function and pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 107 pregnant women with GDM and hyperemesis who underwent delivery in the hospital were enrolled between October 2021 and October 2023.All the patients underwent C13 rapid urease test to record H.pylori infection and,according to the res-ults,were divided into infection group(n=49)and non-infection group(n=58).The glucose metabolism indexes[fasting in-sulin(FINS),insulin resistance index(HOMA-IR),fasting blood glucose(FBG)],lipid metabolism indexes[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]and coagulation function indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT)]were compared between groups.The pregnancy outcomes were recorded.Results The H.pylori in-fection rate in the 107 GDM patients was 45.79％(49/107).The levels of TC,TG,LDL-C,FBG,FINS and HOMA-IR in the infection group were higher group(t=4.939,11.743,7.009,7.883,7.693,9.506;all P＜0.05),while HDL-C was lower(t=12.597,P＜0.05)than in non-infection group,respectively.The PT,APTT and TT in infection group were lower(t=9.414,8.657,6.182;all P＜0.05),while FIB was higher(t=9.255,P＜0.05)than those in non-infection group,respect-ively.The incidences of premature delivery,fetal distress,low birth weight infants and cesarean section in infection group were higher than in non-infection group(x2=3.994,4.409,4.808,5.199,8.314;all P＜0.05)respectively,but there was no difference in the incidence of postpartum hemorrhage between the two groups(x=1.983,P＞0.05).Conclusion The in-cidence of H.pylori infection is higher in GDM patients.H.pylori infection will cause glycolipid metabolism disorder,ab-normal coagulation function and increase the risk of adverse pregnancy outcomes.
NETL
NSTL
万方数据
