The origin,controversy and clinical application of enterotypes:research progress
With the development of microbiome sequencing technology based on bacterial DNA analysis,advances in un-derstanding the intestinal microbiota have been significantly achieved.The intestinal microbiota differs from person to per-son both in terms of time and space,which sets up a long-held barrier to the progress of medical application.Contributing to removing the barrier,the concept of enterotypes has provided a remarkable first step to dimensionality reduction analys-is of intestinal microbiota,bringing convenience to clinical application and research as well.Nevertheless,increasing re-search on enterotypes is raising questions about its existence and rationality.This study sheds light on this question by sum-marizing the latest research findings on enterotypes with respect to their origin,development and clinical applications,hop-ing to not only reach a comprehensive understanding of intestinal homeostasis,but also provide theoretical basis and poten-tial research ideas for the achievement of the most representative and persuasive enterotypes classification models.
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