基于"肠菌-免疫-关节"轴探讨肠道微生物对痛风性关节炎疼痛机制的影响
Influence of gut microorganisms on the pain mechanism of gouty arthritis based on"enterobacteria-immunity-joint"axis
陈培 1舒杨 1李洪辉 1罗志强 1卢承印 1简功辉 2齐新宇 2熊辉2
作者信息
- 1. 湖南中医药大学第一附属医院,湖南长沙 410005
- 2. 湖南中医药大学
- 折叠
摘要
痛风性关节炎(gout arthritis,GA)是一种常见的晶体性关节炎.疼痛是GA发病时最突出的症状,如何缓解GA发作期的炎症疼痛是当前治疗的核心.随着"肠-关节"轴的相互关系不断被证实,研究发现肠道微生物及其代谢产物可以通过调控巨噬细胞介导的GA免疫炎症反应来干预GA疼痛机制.因此,本文就"肠菌-免疫-关节"轴在GA炎症疼痛机制中的研究进展作一综述,旨在通过已发表的相关文献,梳理总结肠道微生物及其代谢产物对巨噬细胞介导的GA炎症疼痛机制的影响以及潜在的机制,以期为未来以肠道微生物为靶点的抗GA镇痛新药的研发,提供文献支持及参考.
Abstract
Gouty arthritis(GA)is a common form of crystalline arthritis.Pain is the most prominent symptom at the onset of GA,and how to relieve the inflammatory pain during GA attacks is the core of current treatment.As the interrelation-ship of the"gut-joint"axis has been confirmed,it has been found that gut microorganisms and their metabolites can inter-fere with GA pain mechanisms by modulating the macrophage-mediated immune inflammatory response to GA.Therefore,this paper reviews the progress in research on the"enterobacteria-immunity-joint"axis in GA inflammatory pain mechan-isms and aims to summarize the published literature on gut microorganisms and metabolites affecting macrophage-medi-ated GA inflammatory pain mechanisms and potential mechanisms,providing literature support and references for the fu-ture development of new anti-GA analgesic drugs targeting gut microorganisms.
关键词
痛风性关节炎/肠道微生物/巨噬细胞/炎症/疼痛Key words
Gouty arthritis/Gut microorganisms/Macrophages/Inflammation/Pain引用本文复制引用
出版年
2024
NETL
NSTL
万方数据