首页|粪菌移植治疗消化道内外疾病的研究进展

粪菌移植治疗消化道内外疾病的研究进展

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粪菌移植(fecal microbiota transplantation,FMT)是将健康个体粪便中的菌群分离并移植到患者肠道内的特殊治疗方式,目前已广泛用于治疗艰难梭菌感染和炎症性肠病等以菌群失调为特征的消化道内疾病。此外,FMT也被用于改善一系列消化道外疾病,如抑郁症、代谢综合征和COVID-19感染等。通过临床实践,人们认识到FMT在治疗菌群相关疾病方面具有较大的潜力,但对FMT后微生物定植的规律尚缺乏全面、系统的认识,这已成为限制FMT广泛应用的主要因素。本文对FMT治疗消化道内外疾病的临床研究进行了总结和详细阐述,以期为FMT的进一步临床应用提供理论指导。
Treatment of digestive and extradigestive diseases with fecal microbiota transplantation:research progress
Fecal microbiota transplantation(FMT)is a special treatment method that separates and transplants the micro-biota from the feces of healthy individuals into the intestinal tract of patients.It has been widely used for treating digestive diseases characterized by dysbiosis such as Clostridium difficile infection and inflammatory bowel disease.In addition,FMT is also used to improve a range of extradigestive diseases,such as depression,metabolic syndrome and COVID-19 in-fection.People recognized that FMT has great potential in treating microbiota-related diseases through clinical practices,but there is still a lack of comprehensive and systematic understanding on the rules of microbial colonization after FMT,which has become an important factor limiting the widespread application of FMT.This article summarizes and elaborates on the clinical research on the treatment of gastrointestinal diseases with FMT,in order to provide theoretical guidance for further clinical application of FMT.

Fecal microbiota transplantationClostridium difficile infectionInflammatory bowel diseaseMetabolic syn-dromeDepression

刘笑彤、杜晓安、王文君、孟欣然、刘宏鑫、范丽君、李运清

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济宁医学院临床医学院,山东济宁 272067

济宁医学院病原生物学教研室

济宁市药理学重点实验室

粪菌移植 艰难梭菌感染 炎症性肠病 代谢综合征 抑郁症

2024

中国微生态学杂志
中华预防医学会 大连医科大学

中国微生态学杂志

CSTPCD北大核心
影响因子:1.115
ISSN:1005-376X
年,卷(期):2024.36(11)