肠道菌群在脓毒症中的关键作用
The key role of gut microbiota:engine of sepsis
邓一航 1王翔2
作者信息
- 1. 南京医科大学附属南京医院重症医学科,江苏南京 210006
- 2. 南京医科大学附属南京医院重症医学科,江苏南京 210006;南京市第一医院重症医学科
- 折叠
摘要
长久以来,人们一直认为肠道在脓毒症的发病机制中发挥着主要作用.肠道菌群是宿主体内生理稳态机制的重要组成部分,通过调节宿主的肠道屏障功能、免疫功能和疾病易感性来维持肠道微生态平衡.然而,脓毒症会导致肠道菌群的组成发生变化,出现菌群失调,表现为益生菌的减少和条件致病菌的增殖,并可能导致不良预后.因此,维持或改善肠道菌群的组成和功能可能是治疗脓毒症的潜在手段.本文通过回顾相关研究,着重关注肠道菌群的病理生理作用机制及其与脓毒症的相互作用,进而阐述微生物疗法在治疗脓毒症中的良好应用前景.
Abstract
For a long time,it has been believed that the gut plays an important role in the pathogenesis of sepsis.The gut microbiota is an important component of the physiological homeostasis mechanisms in the host,which can maintain the balance of gut microecology by regulating host gut barrier function,immune function,and disease susceptibility.However,sepsis can lead to changes in the composition of gut microbiota,resulting in dysbiosis characterized by a decrease in probi-otics and activation of opportunistic pathogens,and may lead to poor outcomes.Therefore,maintaining or improving the composition and function of gut microbiota may be a potential therapeutic approach for treating sepsis.This article reviews related research and focuses on the pathological and physiological mechanisms of gut microbiota and its interactions with sepsis,thereby describing the promising application prospects of microbiome therapeutics in sepsis treatment.
关键词
肠道菌群/脓毒症/菌群失调/免疫/微生物疗法Key words
Gut microbiota/Sepsis/Dysbiosis/Immune/Microbiome therapeutics引用本文复制引用
出版年
2024
NETL
NSTL
万方数据