For a long time,it has been believed that the gut plays an important role in the pathogenesis of sepsis.The gut microbiota is an important component of the physiological homeostasis mechanisms in the host,which can maintain the balance of gut microecology by regulating host gut barrier function,immune function,and disease susceptibility.However,sepsis can lead to changes in the composition of gut microbiota,resulting in dysbiosis characterized by a decrease in probi-otics and activation of opportunistic pathogens,and may lead to poor outcomes.Therefore,maintaining or improving the composition and function of gut microbiota may be a potential therapeutic approach for treating sepsis.This article reviews related research and focuses on the pathological and physiological mechanisms of gut microbiota and its interactions with sepsis,thereby describing the promising application prospects of microbiome therapeutics in sepsis treatment.
Gut microbiotaSepsisDysbiosisImmuneMicrobiome therapeutics
NETL
NSTL
万方数据
