Objective To analyze the risk management mechanism of hospital infection in Pharmacy Intravenous Admixture Services(PIVAS)to optimize the handover process of finished product infusion,so as to reduce the risk of nosocomial infection transmission.Methods Based on Failure Mode and Effect Analysis(FMEA),the risk of nosoco-mial infection transmission during transfusion handover of finished products in PIVAS was evaluated.Failure modes with high risk were selected,failure causes were analyzed,improvement measures were formulated,and management effects were evaluated.Results In the handover process of finished PIVAS products,a total of 7 risk points with RPN>125 were identified and rectified by revising the system,personnel management and training related to hospital infection sys-tem.After 6 months of improvement,the RPN values of 7 high-risk points decreased.Hand hygiene compliance among pharmacists and nurses increased by 36%and 24%,respectively.The time of taking medicine by nurses was shortened from 20.0±8.9 minutes before improvement to 14.0±8.4 minutes after improvement,and the time of taking medicine was shortened by 30%.Conclusion The FMEA was applied to identify and evaluate the risk of nosocomial infection transmission during the handover of finished products transfusion in PIVAS,and a nosocomialinfection transmission risk management mechanism was established,which could timely detect high-risk points in the process and reduce the risk of nosocomial infection transmission.