Objective To optimize the management strategy of colorectal cancer screening program in Wuhan,in order to reduce screening costs and improve screening benefits.Methods Convenience sampling was used to select 39 key informants for interviews.The topic framework analysis method was used to sort out and analyze the interview data.Results Colorectal cancer screening included five key links:publicity mobilization,screening implementation,result notification,diagnosis and treatment,and follow-up management.There were some problems,such as lack of publici-ty and mobilization plan for high-risk groups,short time of screening project,complicated screening process,unquali-fied sample quality,loss of sampling package,neglect of health education,insufficient continuous tracking of positive residents in initial screening,inadequate information sharing between communities and designated hospitals,and lax im-plementation of colonoscopy operation standards.Conclusion It is necessary to establish a long-term mechanism for colorectal cancer screening,fully carry out the publicity and mobilization work,give full play to the role of primary medical and health institutions,and build a hospital-community closed-loop management mode.