Objective To construct an artificial intelligence voice follow-up system for breast cancer patients un-dergoing day surgery and evaluate its clinical application effect.Methods According to the follow-up requirements of breast cancer patients at different stages of day surgery,an artificial intelligence voice follow-up system was designed.The telephone connection rate,follow-up time,information collection integrity rate,field extraction accuracy rate and satisfaction were compared and analyzed.Results A total of 432 patients with breast cancer undergoing day surgery were followed-up by the artificial intelligence voice follow-up system.A total of 1 089 follow-up records were per-formed.The telephone connection rate was 90.9%,the information collection integrity rate was 97.7%,and the field extraction accuracy rate was 94.9%.The average time of the first return visit was(2.1±0.42)min,the average time of the second return visit was(1.6±0.45)min,the average time of the third return visit was(1.9±0.33)min,and the average time of survival follow-up was(2.1±0.32)min,which greatly shortened the follow-up time.Conclusion The artificial intelligence voice follow-up system can build a continuous and fast doctor-patient commu-nication path for breast cancer patients undergoing day surgery,improve the follow-up rate,save labor costs,and im-prove the service quality.