Objective To improve the effectiveness of standardized management of vomit-free wards and reduce the incidence of nausea and vomiting in cancer patients during the peri-chemotherapy period.Methods The health-care failure mode and effect analysis(HFMEA)was used to systematically mine and analyze the risk points in the standardized management process of the non-vomiting ward.By improving the evaluation system,managing patients'medication throughout the process,accurately implementing non-drug antiemetic measures,enriching the education mode and improving follow-up methods,the management effectiveness of the non-vomiting ward was improved.Results The incidence of expected nausea and vomiting was reduced from 10.1%to 3.9%,the incidence of nausea and vomiting was reduced from 22.55%to 13.8%,the incidence of delayed nausea and vomiting was reduced from 18.6%to 8.8%,and the comfort score was increased from 88 to 97 points.Conclusion The application of HFMEA can op-timize the standardized management process of vomit-free wards,reduce the incidence of Chemotherapy-Induced Nau-sea and/or Vomiting in cancer patients,improve patients'comfort,and improve patients'medical experience.