Maresin-1对脓毒症器官保护作用的研究进展
Research progress on the organ-protective effect of Maresin-1 in sepsis
唐立丽 1龚模祥 1陈荍 1苏志勇 1李小悦1
作者信息
- 1. 遵义医科大学第五附属(珠海)医院重症医学科,广东珠海 519100
- 折叠
摘要
脓毒症是宿主对感染产生的炎症反应失控而导致的致命性器官功能障碍.过度炎症反应是脓毒症发生发展的核心环节,器官功能损伤程度与脓毒症预后直接相关,及时干预过度炎症反应、缓解器官功能损伤是改善脓毒症预后的关键.Maresin-1(MaR-1)是一种新近发现的内源性特异性促炎症消退介质,可在脓毒症中发挥抗炎、促炎症消退及器官保护作用,可能是脓毒症治疗的新靶点.本文就MaR-1 参与脓毒症炎症调控的机制及其器官保护作用的相关研究进展进行综述,以期为临床研发新的脓毒症治疗药物提供参考依据.
Abstract
Sepsis is a fatal organ dysfunction caused by the uncontrolled inflammatory response of the host to infection.Excessive inflammatory reaction is the core factor in the occurrence and development of sepsis,the degree of organ dysfunction is directly related to the prognosis of sepsis.Timely intervention of excessive inflammatory response and alleviation of organ function damage are essential to improve the prognosis of sepsis.Maresin-1(MaR-1)is a newly discovered endogenous specific pro-inflammatory resolution mediator,which plays a role of anti-inflammatory,pro-inflammatory regression and organ protection in sepsis,and may be a new target for the treatment of sepsis.This article reviews the research progress of the role of MaR-1 in the regulation of inflammation and organ protection in sepsis,in order to provide reference for the clinical development of new drugs for the treatment of sepsis.
关键词
Maresin-1/脓毒症/脓毒症相关性器官损伤/过度炎症反应Key words
Maresin-1/Sepsis/Sepsis-associated organ injury/Excessive inflammatory reaction引用本文复制引用
基金项目
国家自然科学基金(81960361)
广东省医学科学技术研究项目(B2023238)
出版年
2024
NETL
NSTL
万方数据