Research progress of vagus nerve in regulation of inflammatory response in sepsis
The vagus nerve,as an important"guardian"of the body,is involved in the steady-state regulation of cardiovascular,respiratory,gastrointestinal digestion and endocrine systems.Recent studies have shown that the vagus nerve plays an important regulatory role in inflammatory response via the inflammatory reflex,which is closely related to the fact that the afferent and efferent fibers of the vagus nerve can sense and regulate inflammation,respectively.The pathophysiological mechanism of sepsis is based on the dysregulation of immune response,and it is often initiated by the excessive inflammatory response of the innate immune system.In recent years,in order to expand intervention strategies for the immune dysregulation of sepsis,researchers have made many efforts on regulating the inflammatory response of the vagus nerve in sepsis.This article focuses on the mechanism of vagus nerve-mediated inflammatory reflex and the regulatory role of vagus nerve in inflammatory response of sepsis,in order to reveal new therapeutic strategies for the treatment of sepsis.
Vagus nerveSepsisCholinergic anti-inflammatory pathwayInflammatory reflexNon-neuronal cholinergic system
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