Interaction between NOD-like receptor protein 3 inflammatory corpuscles and mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy
Septic cardiomyopathy(SCM)has a high incidence and complex pathogenesis,which can significantly increase the mortality of sepsis patients.NOD-like receptor protein 3(NLRP3)inflammatory corpuscles play an important role in the pathogenesis of SCM.Mitochondrial dysfunction in cardiomyocytes is also one of the important pathogenesis of SCM.Activation of NLRP3 inflammatory corpuscles is closely related to mitochondrial dysfunction.The study of interaction mechanism between the two is helpful to find a new therapeutic scheme for SCM.This article reviews the interaction between NLRP3 inflammatory corpuscles and mitochondrial dysfunction in the pathogenesis of SCM,as well as the related mechanisms of traditional Chinese medicine(TCM)prevention and treatment of SCM,providing theoretical reference for further exploring therapeutic targets for SCM.
Septic cardiomyopathyNOD-like receptor protein 3Mitochondrial dysfunctionInteraction
NETL
NSTL
万方数据
