非编码RNA在高氧性急性肺损伤中作用的研究进展
Research progress of the role of non-coding RNA in hyperoxia-induced acute lung injury
王太珊 1尹贵珍 2刘国跃1
作者信息
- 1. 遵义医科大学第二附属医院重症医学科,贵州遵义 563000;遵义医科大学,贵州遵义 563000
- 2. 浙江省人民医院毕节医院(毕节市第一人民医院)麻醉科,贵州毕节 551799
- 折叠
摘要
高氧性急性肺损伤(HALI)是临床氧疗的一种主要并发症,在成人主要表现为急性呼吸窘迫综合征(ARDS),在婴幼儿则会导致支气管肺发育不良(BPD),严重影响患者的预后与生活质量,因此越来越受到人们的重视.然而,HALI的发病机制复杂且不明确,目前也无明确的治疗方法.非编码RNA(ncRNA)是一类重要的功能RNA转录体,由于缺少有效开放阅读框,并不具备编码蛋白质的功能;但是,ncRNA仍可在多水平调控基因表达,从而影响多种疾病的发生发展.近年来已有大量体内外研究表明,ncRNA在HALI发生发展过程中具有重要作用.本文就ncRNA在HALI中的表达及意义进行综述,旨在为HALI的防治提供新的诊疗思路.
Abstract
Hyperoxia-induced acute lung injury(HALI)is an important complication of clinical oxygen therapy,which is mainly characterized by acute respiratory distress syndrome(ARDS)in adults and broncho-pulmonary dysplasia(BPD)in infants.HALI seriously affects the prognosis and quality of life of patients,so it has received more and more attention.However,the pathogenesis of HALI is complex and unclear,and there is no clear treatment method at present.Non-coding RNA(ncRNA)is an important type of functional RNA transcriptome.Due to the lack of effective open reading frame,ncRNA does not have the function of coding proteins.However,ncRNA can still regulate gene expression at multiple levels and affect the occurrence and development of many diseases.In recent years,a large number of in vitro and in vivo studies have shown that ncRNA is involved in the pathogenesis of HALI and is of great significance.This article reviews the expression and significance of ncRNA in HALI,in order to provide new diagnosis and treatment ideas for the prevention and treatment of HALI.
关键词
高氧性急性肺损伤/非编码RNA/急性呼吸窘迫综合征/Ⅱ型肺泡上皮细胞/凋亡Key words
Hyperoxia-induced acute lung injury/Non-coding RNA/Acute respiratory distress syndrome/Type Ⅱ alveolar epithelial cell/Apoptosis引用本文复制引用
基金项目
国家自然科学基金(82160369)
贵州省科技计划(2021-096)
贵州省卫生健康委科学技术基金(gzwjkj2021-041)
出版年
2024
NETL
NSTL
万方数据