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星形胶质细胞在脑缺血/再灌注损伤中作用的研究进展

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脑缺血/再灌注损伤(CIRI)的病理生理机制复杂,目前治疗方法有限且疗效不佳.既往针对CIRI的治疗策略大多靶向神经元,但未取得重要进展.目前预期星形胶质细胞可成为治疗CIRI的前景广阔的效应细胞.星形胶质细胞在CIRI病理过程中是一把"双刃剑",对中枢神经系统既有神经毒性作用,又有神经保护作用.如何有效利用星形胶质细胞治疗CIRI成为当前的研究热点.本文综述了星形胶质细胞在CIRI机制中的双重作用,着重阐述了星形胶质细胞缓解CIRI所致氧化应激的相关机制,以期为CIRI治疗提供新的思路.
Research progress on the role of astrocytes in cerebral ischemia/reperfusion injury
The pathophysiological mechanism of cerebral ischemia/reperfusion injury(CIRI)is complex,and the current treatment methods are limited and the efficacy is not good.Previous therapeutic strategies of CIRI mostly target neurons,but no significant progress has been made.At present,astrocytes are expected to be promising effector cells for the treatment of CIRI.Astrocytes are a"double-edged sword"in the pathological process of CIRI,with both neurotoxic and neuroprotective effects on the central nervous system.How to effectively use astrocytes to treat CIRI has become a research hotspot.In this review,the dual roles of astrocytes in CIRI mechanism were reviewed,and the related mechanisms of astrocytes in relieving oxidative stress induced by CIRI were emphasized,in order to provide new ideas for the treatment of CIRI.

AstrocyteCerebral ischemia/reperfusion injuryOxidative stress

张安杨、李钊硕、卢志刚

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荆门市中心医院神经内科,湖北荆门 448000

河南省人民医院(郑州大学人民医院)脑血管病科,郑州 450003

湖北民族大学风湿性疾病发生与干预湖北省重点实验室,湖北恩施 445000

星形胶质细胞 脑缺血/再灌注损伤 氧化应激

国家自然科学基金湖北省自然科学基金河南省科技攻关计划湖北省卫生健康委科研项目河南省医学科技攻关计划湖北省荆门市重点科技计划风湿性疾病发生与干预湖北省重点实验室开放基金

820608132020CFB722232102521024WJ2021M075SBGJ2021020362022YFZD021PT022103

2024

10.3760/cma.j.cn121430-20230922-00813

中华危重病急救医学
中华医学会

中华危重病急救医学

CSTPCD北大核心
影响因子：3.049
ISSN：2095-4352
年,卷(期)：2024.36(4)