内皮细胞机械敏感离子通道蛋白Piezo1在疾病中作用的研究进展
Research progress on the role of endothelial mechanically sensitive ion channel protein Piezo1 in diseases
张笑婷 1刘金海 1邓小明 1薄禄龙1
作者信息
- 1. 海军军医大学第一附属医院麻醉学部,上海 200433
- 折叠
摘要
内皮细胞具有重要的生理功能和与多种疾病发生发展相关的调节作用.机械敏感离子通道蛋白Piezo1广泛分布于机体多种组织中,参与多种疾病的发生发展.Piezo1在内皮细胞中高表达,对内皮细胞功能发挥重要的调控作用.本文对Piezo1的结构与功能、内皮细胞的生理功能及病理损伤机制、内皮细胞Piezo1在多种疾病中作用的研究进展进行综述,以期深入了解内皮细胞Piezo1 的功能和调控机制,为相关疾病的治疗提供新的靶点和策略.
Abstract
Endothelial cells have important physiological functions and regulatory effects related to the occurrence and development of various diseases.Piezo1 is a mechanically sensitive ion channel protein,which is widely distributed in various tissues of the body and participates in the occurrence and development of various diseases.Piezo1 is highly expressed in endothelial cells and plays an important regulatory role in endothelial cell function.This article reviews the structure and function of Piezo1,the physiological function and pathological damage mechanism of endothelial cells,and the role of endothelial cell Piezo1 in various diseases,in order to understand the function and regulation mechanism of endothelial cell Piezo1,and provide new targets and strategies for the treatment of related diseases.
关键词
内皮细胞/Piezo1/心血管系统/呼吸系统Key words
Endothelial cell/Piezo1/Cardiovascular system/Respiratory system引用本文复制引用
出版年
2024
NETL
NSTL
万方数据