线粒体动力学紊乱在脓毒症相关性急性肾损伤发病机制中的作用研究进展
Research progress on the role of mitochondrial dynamics disorder in sepsis-associated acute kidney injury
李竹 1唐立丽 2张杰 2何东蕊 1谭江陆 1李小悦2
作者信息
- 1. 遵义医科大学第五附属(珠海)医院急诊科,广东珠海 519000
- 2. 遵义医科大学第五附属(珠海)医院重症医学科,广东珠海 519000
- 折叠
摘要
脓毒症是宿主对感染反应失控所致的危及生命的器官功能障碍,是急危重症患者死亡的主要原因之一.脓毒症相关性急性肾损伤(SA-AKI)与脓毒症患者预后不良相关,其发病机制复杂,至今仍不明确.线粒体动力学是维持线粒体形态、数量正常及线粒体功能正常运行的关键,是近年来新的研究热点.线粒体动力学紊乱通过调节肾小管功能参与SA-AKI的发生发展,有望成为新的治疗靶点.深入探讨线粒体动力学紊乱在SA-AKI发病机制中的作用有助于寻找更有效的治疗方式,从而提高SA-AKI患者的抢救成功率.
Abstract
Sepsis is a life-threatening organ dysfunction caused by the host's uncontrolled response to infection,and is one of the main causes of death in critically ill patients. Sepsis-associated acute kidney injury (SA-AKI) is associated with the poor prognosis of sepsis patients,and its pathogenesis is complex and still unclear to this day. Mitochondrial dynamics is crucial for maintaining the normal morphology,quantity,number and function of mitochondria,which is a new research hotspot in recent years. Mitochondrial dynamics disorder is involved in the occurrence and development of SA-AKI by regulating renal tubular dysfunction,which is expected to become new therapeutic targets. Deeply exploring the role of mitochondrial dynamic disorders in the pathogenesis of SA-AKI will help to find more effective treatment methods,thereby improving the success rate of rescue in SA-AKI patients.
关键词
脓毒症/脓毒症相关性急性肾损伤/线粒体动力学紊乱Key words
Sepsis/Sepsis-associated acute kidneyinjury/Mitochondrial dynamics disorder引用本文复制引用
出版年
2024
NETL
NSTL
万方数据