首页|散发性预激综合征与PRKAG2基因多态性的关系

散发性预激综合征与PRKAG2基因多态性的关系

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目的 探讨散发性预激综合征与PRKAG2基因多态性的关系.方法 散发性预激综合征患者和健康受试者各65例,提取外周血白细胞基因组DNA,聚合酶链反应扩增PRKAG2基因片段,限制性片段长度多态性技术及DNA片段测序法检测基因多态性.结果 测序结果与NCBI Genebank BLAST软件进行对比,未发现突变点.结论 散发性预激综合征与PRKAG2基因多态性无关.
Relationship between sporadic pre-excitation syndrome and PRKAG2 gene polymorphism
Objective To explore the relationship between sporadic pre-excitation syndrome and PRKAG2 gene polymorphism. Methods Genomic DNA was isolated from peripheral lymphocytes obtained from 65 patients with sporadic pre-excitation syndrome and 65 normal persons. Mutation analysis was performed using purified Polymerase chain reaction(PCR) products to direct sequence analysis on PRKAG2. Results No mutation was identified in the 65 patients and 65 normal persons. Conclusion There is no relationship between PRKAG2 gene polymorphism and sporadic pre-excitation syndrome.

Pre-Excitation Syndromes/geneticsMultienzyme ComplexesProtein-Serine-Threonine KinasesPolymorphism, Genetic

牛永红、李小梅、王晶、张涛、包敏、张宴、赵红、黄立纲

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清华大学第一附属医院心脏中心,北京100016

清华大学第一附属医院检验科,北京100016

预激综合征/遗传学 多酶复合物 蛋白质丝氨酸苏氨酸激酶 多态现象,遗传

清华-裕元医学科学研究基金

20240000582

2012

中国误诊学杂志
中华预防医学会 漯河市中心医院 重庆第九人民医院

中国误诊学杂志

影响因子:0.406
ISSN:1009-6647
年,卷(期):2012.12(3)
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