TACE治疗肝癌的不良反应临床观察
Clinical observation on adverse effects of transcatheter arterial chemoembolization in treatment of hepatic carcinoma
张鸿文 1张芨 1林军 1雷娟 1姚和祥2
作者信息
- 1. 南京军区福州总医院医学影像科介入病房,福建福州 350025
- 2. 南京军区福州总医院普外科,福建福州 350025
- 折叠
摘要
目的 探讨TACE治疗肝癌的不良反应情况,为其临床防治提供依据.方法 通过回顾性分析81例(Childpugh A级)肝癌切除术后复发患者TACE术后出现的不良反应情况,与同期同级的267例初诊中晚期肝癌患者进行对比.结果 复发组ALT、AST在TACE术后1周恢复至术前水平,而STB、DBIL、STP、A、ChE在术后2周恢复至术前水平,无严重不良反应；中晚期组肝功能均需要2周才能恢复至术前水平.结论 Child-pugh A级肝癌在TACE术后肝功能损害为可逆性；TACE对肝脏合成功能及储备功能损伤持续时间长,恢复较慢.
Abstract
Objective To evaluate the adverse effects of transcatheter arterial chemoembolization(TACE) for hepatic carcinoma to provide the basis for its clinical prevention and treatment. Methods Adverse effects of 81 cases with postoperative recurrence of hepatic carcinoma (in Child-pugh A grade) undergoing TACE were retrospectively ana-lyzed, with 267 cases of newly diagnosed as primary hepatic carcinoma in advanced stage undergoing of TACE in the same period for comparison. Results ALT and AST of recurrence group returned to previous levels in one week after TACE, while STB and DBIL.STP, A,and ChE in two weeks. No severe adverse effect was observed. However, the changse of liver function indicators in advanced group all returned to previous levels in two weeks after TACE. Conclusions In Child-pugh A grade of hepatic carcinoma, the damage of liver function is reversible after TACE. However,the damage of liver synthetic function and reserve function last for a longer period of time,and the recovery rate are slower.
关键词
肝肿瘤/治疗/化学栓塞,治疗性Key words
Liver Neoplasms/therapy/Chemoembolization, Therapeutic引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据