The influence of double dose clopidogrel to the ischemic and bleeding events of patients with clopidogrel resistance undergoing percutaneous coronary intervention
Objective To evaluate the efficiency and safety of the patients with clopidogrel resistance prescibed with double dose clopidogrel undergoing percutaneous coronary intervention (PCI). Methods 134 patients with clopidogrel resistance were divided into routine dose group {67 cases) and double dose group (67 cases) according to the result of thromboelastography(TEG), the incidence of the ischemic and bleeding events of two group patients were followed up during in hospital stay and clinical of 6 months after operation. Results Compared with the routine dose group, the incidence of major adverse cardiac events was significantly lower in the double dose group. And there were no significant differences in the incidence of bleeding events between two groups. Conclusions Our data indicates that the incidence of ischemic events of patients with coronary heart disease undergoing PCI may be decreased by increasing the maintenance dose of clopidogrel, and the risk of bleeding may be not increased.
Ticlopidine/analogs & derivativesAngioplasty, Transluminal, Percutaneous CoronaryIschemia/therapeuticuseHemorrhage/therapeutic use
NETL
NSTL
万方数据
维普
