Cutaneous Rosai-Dorfman disease: two cases reports and review of the literature
Objective To investigate the clinicopathologic feature, immunophenotype and differential diagnosis of cu-taneous Rosai-Dorfman disease (CRDD). Methods Clinical manifestation, morphologic features and immunohisto-chemical staining were studied in 2 cases of CRDD, along with a literature review. Results The lesions were charac-terized by the presence of large histiocytes with emperipolesis, accompanied by infiltration of lymphocytes, plasma cells and other inflammatory cells. The large histiocytes had an abundant cytoplasm, pale to eosinophilic in appear-ance. Immunohistochemcal examination showed expression of S-100 protein and CD68 on the histiocytes, but no CD1a and CD34. Conclusions CRDD is known as an idiopathic proliferative disease of histiocytes and is very rare. And it is liable to be misdiagnosed in pathologic diagnosis. Differential diagnosis from other types of fibrohistiocytic proliferation lesions- is recommended.
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维普
