Relationship between BNP level and PRC of patients with stable dilated cardiomyopathy
Objective To interpret B-type natriurenic peptide(BNP)level in patients with stable chronic heart failure (CHF) and to learn whether the change in BNP represents disease progression. Methods To compare change in BNP and biological variation in factors of the renin angiotensin aldosterone system(RAS) in stable CHF patients with dilated cardiomyopathy(DCM) ,the level of BNP and RAS factors were measured in 80 stable DCM patients. Results According to stepwise multivariate analysis,serum BNP at baseline(P = 0. 005) .presence of atrial fibrilla-tion(P=0. 014) ,a high biological variation in plasma renin concentration (PRC,P = 0. 002) were significant inde-pendent dominant factors related to a high biological variation in BNP. Although there was no change in body weight or blood pressure during the 2 months following up study period,the change in hematocritf %) was negatively corre-lated with the change in BNP( % ) (r= - 0. 325 ,P=0. 000 7) and positively correlated with the change in PRC( r= 0. 680, P=0. 001). Conclusions There is significant relationship between biological variation in BNP and biologicao variation in PRC,suggesting that the physiological interaction between natriuretic peptide system and RAS may con-tribute to the biological variation in BNP in stable DCM patients.
NETL
NSTL
万方数据
维普
