膀胱副神经节瘤2例报告并文献复习
Two cases reports and literature review of bladder paraganglioma
华玉兰 1张燕林 1曹敏 1侯海娜1
作者信息
- 1. 首都医科大学燕京医学院附属房山区良乡医院,北京102401
- 折叠
摘要
目的 探讨膀胱副神经节瘤的临床病理及免疫组化特征.方法 对2例膀胱副神经节瘤进行组织病理学观察及免疫组化分析并复习文献.结果 2例大体肿物均有完整包膜.镜下肿瘤细胞排列呈巢状及条索状,其中1例伴有鳞状细胞或腺样分化的器官样结构.细胞大小不等,细胞核圆形、椭圆形、梭形,核分裂罕见.瘤细胞巢间有丰富的大、小血窦.免疫组化瘤细胞CgA、Syn、S-100阳性,CK、CK7、HMB45、CEA阴性.结论 膀胱副神经节瘤是较罕见的肿瘤,诊断依赖于组织病理形态及免疫组化.
Abstract
Objective To study the histopathological and immunohistochemical characteristic of bladder paraganglioma. Methods Two cases of bladder paragangliomas were observed on histopathology and had an immunohistochemical analysis, and related literatures were reviewd. Results Grossly, tumor margins were confined within the capsule. The tumor cells disposed in cords, solid cell nests or clusters,one with squamous or glandular organization in one case. They were different in cells size. Nucleus were usually exhibited round, orbicular ovate or fusiform, and nuclear fission were rare. Blood sinus were affluent in stroma. Immunohistochemical study demonstrated that tumor cell were acted with CgA , Syn and S100, but negatively with CK, CK7, HMB45 and CEA. Conclusions Bladder paraganglioma is a rarely tumor that its diagnosis depended on histopathological observation and immunohistochemical staining.
关键词
膀胱肿瘤/病理学/免疫学/副神经节瘤/病理学/免疫学Key words
Urinary Bladder Neoplasms/pathology/Paraganglioma/pathology引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据