肾病综合征血脂代谢紊乱与血胆红素的关系研究
Relationship between hyperlipidemia and serum bilirubin in nephrotic synodrome
陈征 1王艳 1宋文琪 1徐樨巍1
作者信息
- 1. 首都医科大学附属北京儿童医院检验科 100045
- 折叠
摘要
目的 初探肾病综合征(NS)的高脂血症的发病机制与其血胆红素的关系.方法 患儿禁食6h,空腹抽取静脉血检测总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(CHO)、载脂蛋白B(APOB)、低密度脂蛋白(LDL-C)、载脂蛋白(a) (APOA).结果 NS组血清中TBIL、DBIL、IBIL、均低于正常对照组和肾炎组；NS组血清中TG、CHO、LDL、APOB、LDL-C、APOA均高于正常对照组和肾炎组(P＜0.01)；胆红素与TG、CHO采用相关性分析:TBIL与CHO、TG呈负相关(r=-0.55、P＜0.01；r=-0.41,P＜0.01)；DBIL与CHO、TG呈负相关(r=-0.61,P＜0.01；r=-0.45,P＜0.01);IBIL与CHO、TG呈负相关(r=-0.52,P＜0.01;r=-0.36,P＜0.01).结论 胆红素水平与NS患者血脂的高低呈负相关,NS的血胆红素水平明显偏低.
Abstract
Objective To explore the relationship between hyperlipidemia and serum bilirubin level in nephrotic synodrome. Methods The whole subjects came from three groupes:One was nephritic syndrome. Two was chronic glo-merulonephritis. The last was healthy controls. They named S group.T group, H group. S group was divided intc normal and abnormal lipid parts. All items included TBIL.DBIL.IBIL.TG.CHO, APOB.LDL-C, APOA were de-tectd in vein samples which be obtained at 8:00 AM from the whole subject after stopping all foods and water for 5hours,in the meanwhile some urine bilirubine were detected too. Results Serum bilirubins in S group were lower obviously than T group and H group. Serum bilirubin in normal lipid part of S group was higher than those in abnormal lipid part. Conclusions The level of serum bilirubin is negative related with lipid in nephritic syndrome, and some lower bilirubin.
关键词
肾病综合征/代谢/脂类/血液/胆红素/血液Key words
Nephrotic Syndrome/metabolism/Lipids/Blood/Bilirubin/Blood引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据