首页|肾病综合征血脂代谢紊乱与血胆红素的关系研究

肾病综合征血脂代谢紊乱与血胆红素的关系研究

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目的 初探肾病综合征(NS)的高脂血症的发病机制与其血胆红素的关系.方法 患儿禁食6h,空腹抽取静脉血检测总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(CHO)、载脂蛋白B(APOB)、低密度脂蛋白(LDL-C)、载脂蛋白(a) (APOA).结果 NS组血清中TBIL、DBIL、IBIL、均低于正常对照组和肾炎组;NS组血清中TG、CHO、LDL、APOB、LDL-C、APOA均高于正常对照组和肾炎组(P<0.01);胆红素与TG、CHO采用相关性分析:TBIL与CHO、TG呈负相关(r=-0.55、P<0.01;r=-0.41,P<0.01);DBIL与CHO、TG呈负相关(r=-0.61,P<0.01;r=-0.45,P<0.01);IBIL与CHO、TG呈负相关(r=-0.52,P<0.01;r=-0.36,P<0.01).结论 胆红素水平与NS患者血脂的高低呈负相关,NS的血胆红素水平明显偏低.
Relationship between hyperlipidemia and serum bilirubin in nephrotic synodrome
Objective To explore the relationship between hyperlipidemia and serum bilirubin level in nephrotic synodrome. Methods The whole subjects came from three groupes:One was nephritic syndrome. Two was chronic glo-merulonephritis. The last was healthy controls. They named S group.T group, H group. S group was divided intc normal and abnormal lipid parts. All items included TBIL.DBIL.IBIL.TG.CHO, APOB.LDL-C, APOA were de-tectd in vein samples which be obtained at 8:00 AM from the whole subject after stopping all foods and water for 5hours,in the meanwhile some urine bilirubine were detected too. Results Serum bilirubins in S group were lower obviously than T group and H group. Serum bilirubin in normal lipid part of S group was higher than those in abnormal lipid part. Conclusions The level of serum bilirubin is negative related with lipid in nephritic syndrome, and some lower bilirubin.

Nephrotic Syndrome/metabolismLipids/BloodBilirubin/Blood

陈征、王艳、宋文琪、徐樨巍

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首都医科大学附属北京儿童医院检验科 100045

肾病综合征/代谢 脂类/血液 胆红素/血液

2012

中国误诊学杂志
中华预防医学会 漯河市中心医院 重庆第九人民医院

中国误诊学杂志

影响因子:0.406
ISSN:1009-6647
年,卷(期):2012.12(12)
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