Effect of urinary transforming growth factor-β1 (TGFβ1 ) on Leflunomide in combination with prednisolone in treatment of IgA nephropathy
Objective To observe the effect of leflunomide(LEF) in combination with medium/low dose prednisolone in treatment of IgA nephropathy and its influence on the level of urinary transforming growth factor-β (TGFJ31). Methods 60 IgA nephropathy patients were assigned randomly to two groups: LEF group (n - 30), prednisolone group(n=30). Patients of LEF group were treated LEF plus prednisolone, Patients of prednisolone were treated prednisolone . Enzyme linked immunosorbent assay (ELISA) was used to detect the urinary TGF(31 excretion level before and after treatment. Results Before treatment and 6 months after treatment, the urinary TGFpl and the pro-teinuria in LEF group decreased significantly (P<0. 01). Total response rate were 85. 7% in LEF group. Contracted with prednisolone group, the difference was statistically significant(P<0.05). The difference of incidence of side effects was not statistically significant (p> 05). Conclusion Our findings may suggest that LEF plus medium or low dose prednisoloe has a better effect than that of the same dose of hormone; one of the mechanism might be the inhibition of TGFpl.
NETL
NSTL
万方数据
维普
