Clinical value of determination of β2-MG and SF in patients with myelodysplastic syndrome and megaloblastic anemia
Objective To investigate the clinical value of the determination of serum β2-microglobulintpfe-MG) and fer-ritin(SF) in patients with myelodysplastic syndrome (MDS) and megaloblastic anemia (MA). Methods Serum β2-MG and SF were measured by radioimmunoassay. Results The value of β2-MG in the MDS groups significantly higher than that in control group and MA group(F<0.01). In the patients with different MDS subtypes,the value of β2-MG in refractory anemia with excessive blasts(RAEB-Ⅱ) group was significantly higher than that in refractory a-nemia(RA), refractory cytopenia with multilineage dysplasia(RCMD) and refractory anemia with excessive blasts (RAEB-1) group(P<0.01).The values of SF in RAEB-URAEB-Ⅱ groups were significantly higher than those in RA and RCMD groups(P<0.01). Conclusion United determination of the levels of serum β2-MG and SF have not only important clinical values in the diagnosis and differential diagnosis,but also in the classification and evaluation of MDS.
NETL
NSTL
万方数据
维普
