MDS和MA患者血清β2-微球蛋白及铁蛋白检测的临床意义
Clinical value of determination of β2-MG and SF in patients with myelodysplastic syndrome and megaloblastic anemia
张冬清 1林静华 1焦晓阳 1王雪华 1周焕槟1
作者信息
- 1. 汕头大学医学院第一附属医院检验科,广东 汕头 515041
- 折叠
摘要
目的 了解骨髓增生异常综合征(MDS)和巨幼细胞性贫血(MA)患者血清β2-微球蛋白(β2-MG)、铁蛋白(SF)检测的临床价值.方法 采用放射免疫法对MDS、MA及健康人群血清β2-MG、SF进行检测.结果 MDS 组患者血清β2-MG、SF值均明显高于正常对照组和MA组(P＜0.01)；在MDS各亚型患者中,难治性贫血伴原始细胞增多(RAEB-Ⅱ)组血清β2-MG测定值明显高于难治性贫血(RA)组、难治性血细胞减少伴多系发育异常(RCMD)组和难治性贫血伴原始细胞增多(RAEB-Ⅰ)组(P＜0.01)；RAEB-Ⅰ、RAEB-Ⅱ组血清SF值明显高于RA和RCMD组(P＜0.01).结论 联合检测血清β2-MG、SF值,不仅对于MDS和MA的诊断和鉴别诊断,而且对于MDS的分型及病情判断具有一定的临床意义.
Abstract
Objective To investigate the clinical value of the determination of serum β2-microglobulintpfe-MG) and fer-ritin(SF) in patients with myelodysplastic syndrome (MDS) and megaloblastic anemia (MA). Methods Serum β2-MG and SF were measured by radioimmunoassay. Results The value of β2-MG in the MDS groups significantly higher than that in control group and MA group(F<0.01). In the patients with different MDS subtypes,the value of β2-MG in refractory anemia with excessive blasts(RAEB-Ⅱ) group was significantly higher than that in refractory a-nemia(RA), refractory cytopenia with multilineage dysplasia(RCMD) and refractory anemia with excessive blasts (RAEB-1) group(P<0.01).The values of SF in RAEB-URAEB-Ⅱ groups were significantly higher than those in RA and RCMD groups(P<0.01). Conclusion United determination of the levels of serum β2-MG and SF have not only important clinical values in the diagnosis and differential diagnosis,but also in the classification and evaluation of MDS.
关键词
骨髓增生异常综合征/诊断/巨幼细胞性贫血/诊断/β2-微球蛋白/血液/铁蛋白/血液Key words
Myelodysplastic Syndrome/diagnosis/Megaloblastic Anemia/diagnosis/β2-microglobulin/blood/Ferritin/ blood引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据