非糖尿病终末期肾病患者的胰岛素抵抗与脂质代谢紊乱相关研究
Clinical analysis of the relationship between insulin resistance and lipid metabolism disorder of patients with end-stage non-diabetic renal disease
胡秀慧 1蒋妙华 1李妙英 1陈舜杰2
作者信息
- 1. 上海市杨浦区市东医院风湿肾脏科,上海200000
- 2. 上海市新华医院肾脏风湿科,上海200000
- 折叠
摘要
目的 探讨非糖尿病终末期肾病患者胰岛素抵抗指数与相关脂质代谢紊乱的多因素间的相互关系.方法 测定非糖尿病终末期肾病患者100例及40例正常人的血脂、空腹胰岛素(FINS)、空腹血糖(FBS)、体重指数(BMI)等相关指标,分析胰岛素抵抗指数(Homa-IR)作为胰岛素抵抗指标与脂质代谢相关指标间的关系.结果 经临床数据分析表明,非糖尿病终末期肾病患者与对照组受试者比较,出现血清甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)明显升高(P＜0.05),Homa-IR升高更为显著(P＜0.01),高密度脂蛋白胆固醇(HDL-C)明显减低(P＜0.05),BMI也轻度降低(P＜0.05),但总胆固醇(TC)、FBS、FINS水平变化不大(P＞0.05),同时得到Homa-IR与TG、LDL-C、BMI呈正性关联,与HDL-C呈负性关联.结论 非糖尿病终末期肾病患者的胰岛素抵抗与脂质代谢紊乱之间存在着多因素关联性,为综合性防治非糖尿病终末期肾病提供科学的依据.
Abstract
Objective To discuss the relationship between insulin resistance and the related multiple factors of lipid metabolism disorder of patients with end-stage non-diabetic renal disease (ESRD). Methods The blood lipid, fasting insulin (FINS), fasting blood sugar (FBS), body mass index (BM1) and other indicators of both 100 patients with non-diabetic ESRD and 40 normal people were determined, and the relationship between related indicators of lipid metabolism and the homeostasis model assessment insulin resistance index (Homa IR) as the insulin resistance indicator was analyzed. Results The clinical data showed that compared with subjects in the control group, patients with non-diabetic ESRD showed significantly increased serum triglyceride (TG) and low density lipopratem cholesterol (LDL C) (P<0. OS), and their Homa IR increased more significantly! P<0. 01), while the high density lipo-protein cholesterol (HDLC) reduced obviously (P<0.05), and BMI also decreased slightly (P<0.05), but the total cholesterol (TC) , FBS and FINS changed little (P>0.05). At the meantime, it also showed that Homa IR was positively correlated with TG, LDL C and BMI, while was negatively correlated with HDL C. Conclusions There exists the multiple factor correlation between the insulin resistance and lipid metabolism disorder of patients with non-diabetic ESRD, thereby providing the scientific basis for the integrated prophylaxis and treatment of non-diabetic ESRD.
关键词
肾疾病/胰岛素抗药性/脂类/代谢Key words
Kidney Diseases/Insulin Resistance/Li pids/metabolism引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据