Clinical analysis of the relationship between insulin resistance and lipid metabolism disorder of patients with end-stage non-diabetic renal disease
Objective To discuss the relationship between insulin resistance and the related multiple factors of lipid metabolism disorder of patients with end-stage non-diabetic renal disease (ESRD). Methods The blood lipid, fasting insulin (FINS), fasting blood sugar (FBS), body mass index (BM1) and other indicators of both 100 patients with non-diabetic ESRD and 40 normal people were determined, and the relationship between related indicators of lipid metabolism and the homeostasis model assessment insulin resistance index (Homa IR) as the insulin resistance indicator was analyzed. Results The clinical data showed that compared with subjects in the control group, patients with non-diabetic ESRD showed significantly increased serum triglyceride (TG) and low density lipopratem cholesterol (LDL C) (P<0. OS), and their Homa IR increased more significantly! P<0. 01), while the high density lipo-protein cholesterol (HDLC) reduced obviously (P<0.05), and BMI also decreased slightly (P<0.05), but the total cholesterol (TC) , FBS and FINS changed little (P>0.05). At the meantime, it also showed that Homa IR was positively correlated with TG, LDL C and BMI, while was negatively correlated with HDL C. Conclusions There exists the multiple factor correlation between the insulin resistance and lipid metabolism disorder of patients with non-diabetic ESRD, thereby providing the scientific basis for the integrated prophylaxis and treatment of non-diabetic ESRD.
NETL
NSTL
万方数据
维普
