首页|肝胆管结石合并胆管癌的诊治分析

肝胆管结石合并胆管癌的诊治分析

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目的 探讨肝胆管结石合并胆管癌的诊断、治疗和预后.方法 对广州市花都区人民医院近10 a来收治的肝胆管结石合并胆管癌21例诊治情况作回顾性研究.结果 胆管癌在肝胆管结石患者的发生率为3.3%;术前诊断正确率61.9%;CA199阳性率为76.2%,术前诊断正确率B超为56.3%,CT为67.8%,MRI/MRCP为82.3%,根治性切除肿瘤42.8%,姑息性手术57.2%,根治性切除肿瘤1、2、3a生存率分别为91.3%、71.5%和50.7%;姑息性手术1、2、3a生存率分别为30.3%、18.4%和0.00%.结论 肝胆胆管癌患者中血清CA199升高的敏感性、特异性较高,对胆管癌的患者的诊断有较高的价值;且血清CA199在监测术后复发中也具价值.肝胆管结石合并胆管癌根治性手术能明显延长患者寿命,疗效的关键是早期诊断、早期治疗,争取根治性切除.
The analysis of the clinical characteristics and different diagnosis and therapeutic methods of hepatolithiasis with cholangiocarcinoma
Objective To explore the clinical characteristics and different diagnosis and therapeutic methods of hepatolithiasis with cholangiocarcinoma. Methods The clinical data of 21 patients with hepatolithiasis and cholangiocarcinoma were retrospectively analyzed. Follow up data were available for all the patients. Results The occurrence rate of the hapatolithiasia concomitant with cholangiocarcinoma was 3. 3%. the positive rate of CA199 was 76. 2%. In this series, the correct diagnostic rate of hepatolithiasis associated with aspace-occupying lesion in the liver before operation by ultrasonograph was 56. 3% ,by CT was 67. 8% and MRI/MRCP was 82. Z%. The radical resection rate was 42. 8% and the palliative resection was 57. 2%. The cumulative survival rate sat the 1st,2nd and 3rd year after radical resection were91. 3% ,71. 5%,and 50. 7% respectively. The cumulative survival rate sat the 1st ,2nd and 3rd year after palliative resection were 30. 3%, 18. 4% and 0. 00% respectively . There was no 1 year cumulative survival rate in non-operation patients. Conclusion Long-term recurrent hepatolithiasis , postoperation of biliary tract cholidocholithisis with cholangiocarcinoma , positive CA199 are helpful for the diagnosis of cholangiocarcinoma . Operative removal can improve the survival rate.

Hepatolithiasis/complications/diagnosis/therapyChalangiocarcinoma/complications/diagnosis/therapy

曹天生、江自卓、王健

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广东省广州市花都区人民医院普外科 510800

胆结石/并发症/治疗 胆管肿瘤/并发症/诊断/治疗

2012

中国误诊学杂志
中华预防医学会 漯河市中心医院 重庆第九人民医院

中国误诊学杂志

影响因子:0.406
ISSN:1009-6647
年,卷(期):2012.12(13)
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